Sirtuins Function as the Modulators in Aging-related Diseases in Common or Respectively
نویسندگان
چکیده
IntroductIon According to the demographics, the world population over 60 years will double from 605 million to 2 billion people between 2000 and 2050. Aging is a complex process in which the organism and its ability to respond to external stresses become progressive decline. The degenerative aging process is the major underlying cause for aging‐related diseases, including hypertension, diabetes, neurodegenerative diseases, cancer and so on [Table 1]. Many factors contribute to aging, for example, increased oxidative stress, changes in gene expression, accumulation of DNA damage.[1] Disorders of metabolism and dysfunctions of key enzymes/proteins in metabolism are also implicated in aging‐related diseases. Accumulating studies have revealed that deacetylase Sirtuins exert profound protective functions against aging‐related pathologies for the decline of tissues and organs in the elderly, and experimental and genetic studies have linked Sirtuins activity with delaying aging and extending lifespan.[2‐5]
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